In the last posting, we discussed how improbable it would be for accumulated random mutations to develop into a single functional enzyme. What makes this even more unlikely is that there are thousands of enzymes, which work together closely to produce useful products to maintain life.
Here is an online map that shows how they work together (1):
For example, the rate-limiting enzyme (the “bottle-neck”) in the glycolysis pathway, phosphofructokinase-1, is controlled by the end product of its initial pathway, pyruvate, as well as ATP, an important final product of glycolysis. This keeps the pathway from running when it is not needed. Do you think complex pathways like this came about by unrelated random mutations? I don’t.